Billy Crystal returns to Broadway with 1-man show

Billy Crystal arrives at the annual "Backstage At The Geffen" event at the Geffen Playhouse on Monday, May 13, 2013 in Los Angeles. (Photo by Richard Shotwell/Invision/AP)

Billy Crystal arrives at the annual "Backstage At The Geffen" event at the Geffen Playhouse on Monday, May 13, 2013 in Los Angeles. (Photo by Richard Shotwell/Invision/AP)

NEW YORK (AP) ? There are apparently a few more Sundays left in Billy Crystal.

The star of "City Slickers" and "When Harry Met Sally" said Tuesday he will reprise his funny and poignant one-man autobiographical show "700 Sundays" on Broadway for a 9-week stand this fall.

"700 Sundays" was a Broadway success during the 2004-2005 season, playing to sold-out houses and winning a Tony Award for special theatrical experience. Crystal took it on the road, both in America and abroad.

Previews of its return engagement will begin Nov. 5 at the Imperial Theatre, with an opening night set for Nov. 13. The final performance is scheduled for Jan. 5.

In a statement, the New York-bred Crystal said the show ? which makes its first return to New York since its Broadway debut ? will mark its final performances.

"I've now decided to tell this story one last time in my own backyard, where it all took place," he said. "It is a privilege to return to Broadway to say goodbye to one of the greatest thrills of my life."

Loss triggers the stories in "700 Sundays," the centerpiece being the death of Crystal's father, Jack, who died of a heart attack at age 54 when his son, Billy, was 15.

The show's title comes from a calculation by Crystal that father and son spent that many Sundays together before Jack Crystal died. Sunday was the one day of the week the two had to enjoy each other's company since Jack Crystal always held two or three jobs.

Other relatives from Crystal's suburban Long Island childhood pop up, too, in "700 Sundays": Uncle Milt, who founded the legendary Commodore Records; Uncle Berns and Aunt Sheila, among others.

The show, written with good friend Alan Zweibel, will also feature its original director, Des McAnuff. It became the highest grossing nonmusical in Broadway's history.

In 2009, Crystal reprised the show with engagements in six major cities, including Philadelphia, Dallas, Miami, Atlanta and Washington, D.C. The work was also turned into a book.

Crystal forged his comedy career in such diverse television shows as "Soap" and "Saturday Night Live," and movies such as " Deconstructing Harry" and "Analyze This" as well as gigs on the Academy Awards.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-14-US-Theater-Billy-Crystal/id-d77f70c49f1842f48aa2506afc1598a1

eric cantor HGTV Sugar Bowl 2013 chick fil a chick fil a rose parade bowl games

Savannah Guthrie: Engaged to Michael Feldman!

Source:

blake shelton chelsea handler hannibal Lena Headey roger ebert north korea Daddy Yankee

Your immune system: On surveillance in the war against cancer

Monday, May 13, 2013

Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most deadly types of breast cancer.

"We know that one function of our immune system is to detect and destroy pre-malignant cells before they can become cancer," said lead author Lance D. Miller, Ph.D., associate professor of cancer biology at Wake Forest Baptist. "However, sometimes the immune system becomes unresponsive to the presence of these cells and a tumor develops."

This unresponsiveness can be temporary, and the immune system can remain alerted to the fact that there's a problem. Immune cells can stand post along the borders of the tumor and even infiltrate the tumor core, where they may gain a better position for eventual attack. "We now have technologies that allow us to quantify aspects of this interaction and from that information we can make predictions about cancer outcomes, Miller said."

The study published online ahead of print last month in the journal Genome Biology.

This approach is known as gene expression profiling, and by studying the expression profiles of 2,000 human breast tumors, Miller and his team identified several immune gene signatures that reflect the abundance and anti-tumor properties of different types of tumor-infiltrating immune cells. They found that in certain aggressive types of breast cancer, such as basal-like or triple negative disease, these immune signatures were highly predictive of cancer recurrence years after initial treatment.

"Strikingly, the patients who seemed to benefit the most were those with highly proliferative and clinically aggressive disease," Miller said. "In these cases, high expression levels of the immune genes predicted for recurrence-free survival, while low immune gene expression predicted for a high likelihood of cancer recurrence."

An important next step, Miller said, will be translating this into a diagnostic test that may help doctors make more informed treatment decisions.

"Knowing a tumor's immunogenic disposition could help oncologists know whether to prescribe more or less aggressive treatment regimens, or perhaps, to know which drugs, specifically, will be most effective," he said.

For doctors like Bayard Powell, M.D., chief of hematology and oncology at Wake Forest Baptist's Comprehensive Cancer Center, new drugs designed to enhance anti-tumor immune responses are beginning to play a major role in the treatment of certain forms of cancer.

"At Wake Forest Baptist we are now fighting cancer with state-of-the-art therapies including immunotherapeutics," Powell said. "How a tumor's immunogenic disposition influences the effectiveness of immunotherapeutic drugs is an important question that could lead to valuable new strategies in personalized medicine."

###

Wake Forest Baptist Medical Center: http://www.wfubmc.edu

Thanks to Wake Forest Baptist Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 29 time(s).

Source: http://www.labspaces.net/128198/Your_immune_system__On_surveillance_in_the_war_against_cancer

Sandy Hook Hoax 2014 Corvette Stacie Halas Corvette Stingray Claire Danes Amy Poehler Australian Open

PFT: Texans pass on signing Collin Klein

AP

With the Bears, Bills, Chargers, Eagles and Jaguars beginning OTAs (organized team practice activity) on Monday, here is a primer on what teams can and can?t do as spelled out by the collective bargaining agreement between players and owners. Here are some of the major points:

OTAs are voluntary workouts. On-field coaching instruction is allowed, but live contact is prohibited.?Per the CBA, prohibited contact includes ?blocking, tackling, pass rushing [and] bump-and?-run? situations.?Players can wear helmets, elbow pads and knee pads, but OTAs are not to be fully padded practices.

Some offense vs. defense team drills are allowed during OTAs; for instance, 11-on-11 drills can be conducted. Some special teams work is also allowed. However, no one-on-one workouts can occur, such as a receiver competing against a cornerback.

During OTAs, players are limited to two hours of on-field practice time and no more than six hours of total work in a given day.

As with all on-field organized offseason workouts, clubs are required to record OTAs and keep the recordings on file until early October (30 days after the start of the regular season). The NFLPA has the right to observe a limited number of offseason workouts in-person and can request practice video from a club if a complaint is filed.

If a workout violation is alleged, the NFL and NFLPA will first work toward a solution; if they cannot come to an agreement, an independent arbitrator will take up the matter and make a ruling.

According to the CBA, a team and its head coach ?are jointly responsible for any conduct in violation? of offseason workout rules, and fines can be levied by Commissioner Roger Goodell if necessary. For a first upheld violation, head coach can be fined up to $100,000, with a club fined as much as $250,000. However, the commissioner can wave fines or impose smaller penalties depending upon the nature of the violation.

In the event of a workout rules breach, a team will lose its ?next scheduled week of OTAs,? per the CBA. A second workout violation in the same league year will cost a club a fourth-round pick in the next draft as well as another week of OTAs.

Finally, here is a schedule of workouts for all 32 teams.

Source: http://profootballtalk.nbcsports.com/2013/05/12/texans-like-klein-but-not-enough-to-sign-him/related/

joseph kony joseph kony ipad 3 release date apple store down apple live blog ohio primary cell phone jammer

Pakistan's Sharif wants good relations with US

Supporters of Pakistan's former Prime Minister Nawaz Sharif celebrate the victory of their leader in Islamabad, Pakistan on Sunday, May 12, 2013. Sharif looked set Sunday to return to power for a third term, with an overwhelming election tally that just weeks ago seemed out of reach for a man who had been ousted by a coup and was exiled abroad before clawing his way back as an opposition leader. (AP Photo/B.K. Bangash)

Supporters of Pakistan's former Prime Minister Nawaz Sharif celebrate the victory of their leader in Islamabad, Pakistan on Sunday, May 12, 2013. Sharif looked set Sunday to return to power for a third term, with an overwhelming election tally that just weeks ago seemed out of reach for a man who had been ousted by a coup and was exiled abroad before clawing his way back as an opposition leader. (AP Photo/B.K. Bangash)

RAIWIND, Pakistan (AP) ? The Pakistani politician poised to become the country's next prime minister said Monday that Islamabad has "good relations" with the United States, but called the CIA's drone campaign in the country's tribal region a challenge to national sovereignty.

Nawaz Sharif spoke to reporters from his family's estate outside the eastern city of Lahore on Monday, two days after his Pakistan Muslim League-N party won a resounding victory in national elections.

His comments were the first indication since the vote about how he would approach relations with the U.S., a strategic ally with whom Pakistan has often been at odds.

Some of his rhetoric on the campaign trail suggested he could have a more adversarial relationship with Washington than the outgoing government. Sharif also was outspoken in his opposition to drone strikes, which are unpopular in Pakistan.

However, analysts caution that while such rhetoric sells on the campaign trail where anti-American sentiment is high, Sharif would likely take a more nuanced approach to U.S. relations once in office.

"I think we have good relations with the United States of America. We certainly have to listen to each other," he said. "If there are any concerns on any side, I think we should address those concerns."

The CIA's drone campaign targeting al-Qaida and other militants in the tribal regions has been extremely controversial in Pakistan where people say it frequently kills innocent civilians ? something Washington denies ? and that it violates Pakistan's sovereignty.

"Drones indeed are challenging our sovereignty. Of course we have taken this matter up very seriously. I think this is a very serious issue, and our concern must be understood properly," said Sharif.

Pakistan occupies a strategic location next to Afghanistan and will likely play a strong role in any reconciliation deal with Taliban militants there. Also, much of the American military equipment that must be shipped out of Afghanistan when the international coalition there ends its combat mission in 2014 will go through the port city of Karachi in southern Pakistan.

Sharif said that he would facilitate the U.S. withdrawal from Afghanistan.

"American troops are being withdrawn in 2014. We will extend full support to them. We will see that everything goes well and smoothly," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-13-Pakistan/id-5a939ee69ffe4bd88fc19a546823edc6

petrino arkansas roy williams divine mercy chaplet matt lauer albert pujols the shining mariano rivera

As I Lay Dying Trailer: Arrived!

Source: http://www.thehollywoodgossip.com/2013/05/as-i-lay-dying-trailer-arrived/

turkey Pumpkin Pie Recipe wii u wii u American Music Awards turkey brine Imessage Not Working

Let Me Tell You All About My Narcissism

Do millennials really suffer from narcissistic personality disorder, or do they act self-absorbed because they're young?

Photo by Piksel/iStockphoto/Thinkstock

The most recent Time cover story calls the generation of young adults known as millennials ?lazy, entitled narcissists.? Writer Joel Stein points out, ?The incidence of narcissistic personality disorder is nearly three times as high for people in their 20s as for the generation that's now 65 or older, according to the National Institutes of Health; 58 percent more college students scored higher on a narcissism scale in 2009 than in 1982.? How do you measure narcissism?

By getting people to talk about themselves. In the 2008 NIH study that Stein cites, researchers did face-to-face interviews with more than 30,000 participants to test them for symptoms of narcissistic personality disorder. The paper described the disorder as a ?pervasive pattern of grandiosity, need for admiration, interpersonal exploitiveness, and lack of empathy.? To be diagnosed as clinically narcissistic, a respondent had to admit to at least one symptom that "caused social or occupational dysfunction." Among its findings, the study diagnosed 9.4 percent of respondents ages 20 to 29 with NPD, compared with 3.2 percent in respondents ages 65 and older.

Attempting to measure narcissism is a thorny issue because each researcher culls data from different data sets, then applies different algorithms to analyze those data sets, then comes to his own conclusions using the result of his methodology. As an article at the Atlantic pointed out last week, many psychologists have disputed the study Stein cited about millennials being singularly narcissistic. And while the NIH study found incidence of narcissistic personality disorder is inversely related to age, its authors admit "NPD may be more prevalent among young adults due to developmental challenges in the transition from adolescence to adulthood."

There?s debate in psychology over whether narcissism should be considered a clinical disorder at all or whether it?s simply a stop on the continuum of natural human emotion. Some psychologists tried unsuccessfully to remove the disorder from the upcoming fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, due out this month.

But are young adults today actually more narcissistic than their elders, or is young adulthood a generally selfish stage of human development? Some experts say there?s no real way to find a definite measure for NPD among the hazy definitions, shifting cultural norms, and evolving technology.

Explainer thanks Brent Donnellan of Michigan State University, Jeffrey Arnett of Clark University, Jean Twenge of San Diego State University, and Donna Bender of the NIH.

Source: http://feeds.slate.com/click.phdo?i=e435d478b0e6b08c0db7670971cf8e26

amzn white house correspondents dinner phoenix coyotes bruce irvin charlie st cloud nba playoffs rosario dawson